Source · Prevention of Future Deaths

Hireiti Kuflesion

Ref: 2015-0414 Date: 23 Oct 2015 Coroner: Emma Brown Area: Birmingham and Solihull Responses identified: 0 / 6 View PDF

Pregnant women with mechanical heart valves received insufficient Clexane dosing and monitoring, combined with clinicians' lack of understanding of thrombosis risks, resulting in delayed diagnosis.

Date 23 Oct 2015
56-day deadline 18 Dec 2015 est.
Responses identified 0 of 6
Hospital Death (Clinical Procedures and medical management) related deaths

Coroner's concerns

AI summary
Pregnant women with mechanical heart valves received insufficient Clexane dosing and monitoring, combined with clinicians' lack of understanding of thrombosis risks, resulting in delayed diagnosis.
View full coroner's concerns
In giving evidencel stated that from time to time she does see at her Obstetric/Cardiac clinic pregnant patients with mechanical valves who have had their warfarin changed to celxane at other hospitals in the region on too low a dose of clexane and that review of their anti-factor Xa may not have been arranged to occur with adequate frequency. Therefore pregnant women with mechanical valves maybe at risk from being prescribed insufficient doses of clexane with insufficient review of their anti-factor Xa_ (2) It was apparent from evidence given by clinicians at the Birmingham Heartlands Hospital that they did not understand the extent and gravity of the increased risk of thrombosis to pregnant women with mechanical valves and this affected the course of investigations into the deceased"s condition ultimately resulting in a delay in diagnosis until it was too late_ Whilst this issue has nOw been brought to the full attention of all departments within the Birmingham Heartlands Hospital that are at real risk of a pregnant patient with a mechanical heart valve presenting to them it is reasonable to assume that clinicians without specialist cardio-obstetric knowledge across the region do not appreciate the implications of a mechanical heart valve in for a pregnant patient:

Report sections

Investigation and inquest
On 25"h February 2015 commenced an investigation into the death of Hireiti Kufletsion. The investigation concluded at the end of the inquest on 13"h October 2015. The medical cause of death was Multi Organ Failure due to Acute Thrombosis of mechanical mitral valve in the first trimester of pregnancy due to emergency cardiac surgery for acute decompensation due to rheumatic mitral valve disease after previous pregnancy. The conclusion of the Inquest was that death was a result of complications from the presence of a mechanical mitral valve during pregnancy that was compounded by a series of failures in medical care
Circumstances of the death
The deceased passed at the Queen Elizabeth Hospital Birmingham on the 2Oth November 2014 as a result of thrombosis of a mechanical mitral valve The deceased had undergone surgery for the placement of a mechanical mitral valve at the Queen Elizabeth Hospital in January 2012 for rheumatic valve stenosis. She was therefore on warfarin therapy and had been advised to avoid pregnancy The deceased had found she was pregnant in October 2014 and following detailed consideration and advice at the joint Cardiac/Obstetric Clinic run by Consultant Cardiologist; and Consultant Obstetrician, at the Birmingham Women's Hospital on the 11 November 2014 had decided to proceed to termination of her pregnancy at 8 weeks gestation, the of the termination being deliberately planned to minimise complications. However; following admission to the Birmingham Heartlands Hospital on the 12th November 2014 in respiratory distress there were failures on the part of the cardiology team to adequately investigate complications of the mechanical valve, namely: (a) an urgent trans thoracic echocardiogram was not performed on the 13th November 2014; (b) when trans thoracic echocardiogram was performed on the 14th November 2014 it did not adequately view the mitral valve and could not be safely interpreted as excluding a problem with the valve; (c) the trans thoracic echocardiogram was misleading reported verbally and in writing as showing right heart failure secondary to a respiratory condition; (d) a consultant review andlor advice from Cardiologists at the University Hospital of Birmingham were not sought away timing

It is likely that with full investigation of mitral valve function the diagnosis of thrombosis would have been made on the 13th or 14th November 2014 When the diagnosis was made on the 17th November 2014 the deceased was too ill for surgery: With diagnosis earlier it is likely that the deceased would have been transferred to the Queen Elizabeth Hospital and surgery could have been undertaken and death would have been avoided. Failures of clinicians at the Birmingham Heartlands Hospital to prescribed adequate doses of clexane between the 28th and 11th November and the 12th and 14th November 2014 contributed to the development of the fatal thrombosis
Action should be taken
In my opinion action should be taken to prevent future deaths and believe you [ANDIOR your organisation] have the power to take such action: A review is required of the current local guidelines, recommendations and procedures for the provision of advice from_ where necessary referral to, the joint Cardiac-Obstetric Clinic operated by UHB and BWH:

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Report details

Reference
2015-0414
Date of report
23 October 2015
Coroner
Emma Brown
Coroner area
Birmingham and Solihull

Responses identified

Responses identified 0 of 6
6 responses not yet linked

Organisations named in PFD reports are normally expected to respond within 56 days. Deadline: 18 Dec 2015 (estimated).

Sent to

Birmingham Women’s NHS Trust
British Cardiovascular Society
N.I.C.E
Royal College of Obstetricians and Gynaecologists
Royal College of Physicians
University Hospitals Birmingham NHS Trust

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