Class 4 Medicines Defect Information: Dr. Reddy's Laboratories (UK) Ltd, Finasteride 5mg Tablets, PL 08553/0261 (EL (20)A/03)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Source · Drug & device safety alerts
MHRA Drug & Device Safety Alerts
1,501 individual alerts
447 medicines recalls & defect notices
766 weekly / monthly index pages
Oct 2009 – Jul 2026
Drug safety updates, medicines recalls, device safety information and field safety notices published by the Medicines and Healthcare products Regulatory Agency. Source: MHRA alerts and recalls on GOV.UK.
Showing 2,267 publications of 2,267
Medical Device Alerts issued in December 2019
A periodic index page listing other alerts and letters, not a single alert.
Mecasermin (Increlex▼): risk of benign and malignant neoplasia
An article in MHRA's monthly Drug Safety Update bulletin.
E-cigarette use or vaping: reporting suspected adverse reactions, including lung injury
An article in MHRA's monthly Drug Safety Update bulletin.
Ondansetron: small increased risk of oral clefts following use in the first 12 weeks of pregnancy
An article in MHRA's monthly Drug Safety Update bulletin.
Class 2 Medicines Recall: LEO Laboratories Ltd, Picato 150 mcg/g gel ▼, EU/1/12/796/001, Picato 500 mcg/g gel ▼, EU/1/12/796/002 (EL (20)A/02)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Field Safety Notice: 20 to 24 January 2020
A weekly index of the field safety notices manufacturers issued that week.
Letters and drug alerts sent to healthcare professionals in December 2019
A periodic index page listing other alerts and letters, not a single alert.
Field Safety Notice: 13 to 17 January 2020
A weekly index of the field safety notices manufacturers issued that week.
Class 4 Medicines Defect Information: Advanz Pharma Zapain 30mg/500mg Tablets (Codeine Phosphate /Paracetamol), PL12762/0034, (EL(20)A/01)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Field Safety Notice: 06 to 10 January 2020
A weekly index of the field safety notices manufacturers issued that week.
Field Safety Notice: 30 December 2019 to 3 January 2020
A weekly index of the field safety notices manufacturers issued that week.
Field Safety Notice: 16 to 20 December 2019
A weekly index of the field safety notices manufacturers issued that week.
Company led drug alert – Paclitaxel 6 mg/ml concentrate for solution for infusion (25ml vials)
A recall the marketing authorisation holder initiated, published by MHRA.
Domperidone for nausea and vomiting: lack of efficacy in children; reminder of contraindications in adults and adolescents
An article in MHRA's monthly Drug Safety Update bulletin.
Class 2 Medicines Recall: Medley Pharma Limited, Ranitidine 150mg Tablets BP, PL 43870/0026, Ranitidine 300mg Tablets BP, PL 43870/0027 (EL(19)A/41)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Letters and drug alerts sent to healthcare professionals in November 2019
A periodic index page listing other alerts and letters, not a single alert.
Field Safety Notice: 09 to 13 December 2019
A weekly index of the field safety notices manufacturers issued that week.
BritePro Solo and BriteBlade Pro single-use fibre optic laryngoscope blades and handles – risk of choking (MDA/2019/044)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Field Safety Notice: 02 to 06 December 2019
A weekly index of the field safety notices manufacturers issued that week.
Class 2 Medicines recall: Ranitidine 150mg Film-Coated Tablets, PL 20075/0063, Ranitidine 300mg Film-Coated Tablets, PL 20075/0064 (EL(19)A/40)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Spectra Optia apheresis: anticoagulant bags used with ‘Correct Connect’ connectors – risk of unbroken ‘frangible’ connector during use (MDA/2019/041)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Field Safety Notice: 25 to 29 November 2019
A weekly index of the field safety notices manufacturers issued that week.
Class 2 Medicines recall: Emerade 150, 300 and 500 microgram solution for injection in pre-filled syringe (EL(19)A/39)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Field Safety Notice: 18 to 22 November
A weekly index of the field safety notices manufacturers issued that week.
Yellow fever vaccine: stronger precautions in people with weakened immunity and in those aged 60 years or older
An article in MHRA's monthly Drug Safety Update bulletin.
Letters and drug alerts sent to healthcare professionals in October 2019
A periodic index page listing other alerts and letters, not a single alert.
Carfilzomib (Kyprolis▼): risk of reactivation of hepatitis B virus
An article in MHRA's monthly Drug Safety Update bulletin.
Class 2 Medicines recall: Ranitidine 75mg Tablets, (Various Liveries) (EL(19)A/37)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Medical Device Alerts issued in October 2019
A periodic index page listing other alerts and letters, not a single alert.
Class 2 Medicines Recall: Ranitidine Oral Solution 30mg/ml, PL 31862/0023, Ranitidine 150mg Tablets, PL 11311/0138 (EL(19)A/36)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Class 3 Medicines Recall: Folic Acid Tablets BP 5mg, PL 0142/5522, (EL(19)A/35)
MHRA class: the defect is unlikely to cause harm; recall is on other grounds.
Field Safety Notice: 11 to 15 November
A weekly index of the field safety notices manufacturers issued that week.
Field Safety Notice: 04 to 08 November 2019
A weekly index of the field safety notices manufacturers issued that week.
Class 2 Medicines Recall: Sandoz Limited, Omeprazole 40 mg Powder for Solution for Infusion, PL 04416/0701 (EL(19)A/34)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Class 2 Medicines Recall: Kyowa Kirin Limited Mitomycin-C Kyowa, All Strengths (see alert for more information), (EL (19)A/33)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Class 2 Medicines Recall: M&A Pharmachem Limited Paracetamol 500 mg Tablets, 1 x 1000, PL 04077/0001, (EL(19)A/32)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Field Safety Notice: 28 October to 1 November
A weekly index of the field safety notices manufacturers issued that week.
Professional use defibrillator/monitor: Efficia DFM100 (Model number 866199) – risk of failure to switch on or unexpected restart (MDA/2019/039)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Class 2 Medicines Recall: Nutriflex Omega Plus 1250ml, 1875ml and 2500ml, PL 03551/0119, and Nutriflex Omega Special 625ml, 1250ml, 1875ml and 2500ml, PL 03551/0118 and Supplemented Product codes ASNSPOMCA, ASNSPOMSVA, ASNPLOMCA, ASNPLOMSVA (625ml, 1250ml, 1875ml 2500ml) (EL(19)A/31)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Field Safety Notice: 21 October to 25 October
A weekly index of the field safety notices manufacturers issued that week.
Class 2 Medicines recall: Ranitidine 150mg/10ml Oral Solution (EL (19)A/29)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Class 2 Medicines recall: Zantac 75 Relief Tablets, Zantac 75 Tablets, Galpharm Indigestion Relief 75mg Tablets, Boots Heartburn & Indigestion Relief 75mg Tablets, Kirkland Indigestion Relief 75mg Tablets, Morrisons Indigestion & Heartburn Relief 75mg Tablets, Boots Heartburn & Indigestion Relief 75mg Tablets (EL (19)A/30)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Company led drug alert – Avonex 30 micrograms/0.5ml Solution for Injection
A recall the marketing authorisation holder initiated, published by MHRA.
Class 2 Medicines recall: Sayana Press 104mg/0.65ml (MDR 055-06/19)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Company led drug alert – Docetaxel Injection 80mg /8ml
A recall the marketing authorisation holder initiated, published by MHRA.
Field Safety Notice: 14 October to 18 October
A weekly index of the field safety notices manufacturers issued that week.
Prescribing medicines in renal impairment: using the appropriate estimate of renal function to avoid the risk of adverse drug reactions
An article in MHRA's monthly Drug Safety Update bulletin.
Nivolumab (Opdivo): reports of cytomegalovirus (CMV) gastrointestinal infection or reactivation
An article in MHRA's monthly Drug Safety Update bulletin.
Adrenaline auto-injectors: recent action taken to support safety
An article in MHRA's monthly Drug Safety Update bulletin.
About this source
Individual alerts by type
Read the chart values
| Alert type | Individual alerts |
|---|---|
| Drug Safety Update | 713 |
| Class 1 Medicines Recall | 6 |
| Class 2 Medicines Recall | 159 |
| Class 3 Medicines Recall | 68 |
| Class 4 Medicines Defect Information | 179 |
| Company-Led Medicines Recall | 35 |
| Device Safety Information | 21 |
| Medical Device Alert | 40 |
| National Patient Safety Alert | 11 |
| MHRA Safety Roundup | 16 |
| Unclassified | 253 |
The MHRA regulates medicines and medical devices in the UK and publishes safety communications on GOV.UK in two streams: the monthly Drug Safety Update bulletin, and Alerts and recalls for drugs and medical devices. This page holds 2,267 of those publications, issued between October 2009 and July 2026.
MHRA classes a medicines recall by the hazard the defect presents: Class 1 life-threatening or serious, Class 2 could cause illness or mistreatment, Class 3 unlikely to cause harm, and Class 4 a caution in use rather than a recall, with the product staying available. A device notice is published as Device Safety Information, or, until 2021, as a Medical Device Alert.
What is not here. We hold each publication's title, type, date and link, not its text: read the alert on GOV.UK for the affected products and the actions MHRA asks for. An alert names a medicine or device and a clinical audience, not an organisation, so no alert on this page is linked to an NHS trust or other responsible body. The weekly “Field Safety Notices” pages are MHRA's own index of the notices manufacturers issued that week, not single alerts, and are counted separately above.