Prescribing medicines in renal impairment: using the appropriate estimate of renal function to avoid the risk of adverse drug reactions
An article in MHRA's monthly Drug Safety Update bulletin.
Source · Drug & device safety alerts
MHRA Drug & Device Safety Alerts
1,501 individual alerts
447 medicines recalls & defect notices
766 weekly / monthly index pages
Oct 2009 – Jul 2026
Drug safety updates, medicines recalls, device safety information and field safety notices published by the Medicines and Healthcare products Regulatory Agency. Source: MHRA alerts and recalls on GOV.UK.
Showing 2,267 publications of 2,267
Ingenol mebutate gel (Picato▼): increased incidence of skin tumours seen in some clinical studies
An article in MHRA's monthly Drug Safety Update bulletin.
Adrenaline auto-injectors: recent action taken to support safety
An article in MHRA's monthly Drug Safety Update bulletin.
Class 2 Medicines recall: Ranitidine Effervescent Tablets 150mg, Ranitidine Effervescent Tablets 300mg (EL (19)A/27)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Class 4 Medicines Defect Information: Xonvea 10 mg/10 mg gastro-resistant tablets (MDR 025-10/19)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Class 4 Medicines Defect Information: Rifadin (rifampicin) 150mg Capsules (MDR 127-09/19)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Field Safety Notice: 7 October to 11 October
A weekly index of the field safety notices manufacturers issued that week.
Prismaflex haemofiltration systems installed with software versions 8.10, 7.20 and lower – risk of unexpected machine shutdown during treatment (MDA/2019/037)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Intraoperative probe cover with long Surgi-tip – risk of infection due to manufacturing failure (specific lot numbers affected) (MDA/2019/034)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Class 2 Medicines recall: Zantac Injection 50mg/2ml, Zantac Syrup 150mg/10ml, Zantac Tablets 150mg, Zantac Tablets 300mg (EL (19)A 24)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Anaesthetic face masks – Specific Intersurgical Economy 22F taper connection may be oversized and leak or disconnect from the breathing circuit (MDA/2019/033)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Field Safety Notice: 30 September to 04 October
A weekly index of the field safety notices manufacturers issued that week.
Breathing circuit swivel elbow – recall due to risk of cracks forming before or during use (MDA/2019/032)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Field Safety Notice: 23 to 27 September
A weekly index of the field safety notices manufacturers issued that week.
Field Safety Notice: 16 to 20 September 2019
A weekly index of the field safety notices manufacturers issued that week.
Class 2 Medicines Recall: Bisacodyl 10mg Suppositories EL (19)A/22
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Field Safety Notice: 09 to 13 September 2019
A weekly index of the field safety notices manufacturers issued that week.
Montelukast (Singulair): reminder of the risk of neuropsychiatric reactions
An article in MHRA's monthly Drug Safety Update bulletin.
Fingolimod (Gilenya▼): increased risk of congenital malformations; new contraindication during pregnancy and in women of childbearing potential not using effective contraception
An article in MHRA's monthly Drug Safety Update bulletin.
Elmiron (pentosan polysulfate sodium): rare risk of pigmentary maculopathy
An article in MHRA's monthly Drug Safety Update bulletin.
Medical Devices Alerts issued in August 2019
An article in MHRA's monthly Drug Safety Update bulletin.
Letters and drug alerts sent to healthcare professionals in August 2019
A periodic index page listing other alerts and letters, not a single alert.
All models of T34 ambulatory syringe pumps – updated cleaning advice and maintenance requirements due to the risk of fluid ingress (MDA/2019/030)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Class 2 Medicines Recall: Aripiprazole 1mg/ml oral solution EL (19)A/21
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Field Safety Notice: 02 to 06 September 2019
A weekly index of the field safety notices manufacturers issued that week.
Field Safety Notice: 27 to 30 August 2019
A weekly index of the field safety notices manufacturers issued that week.
Hormone replacement therapy (HRT): further information on the known increased risk of breast cancer with HRT and its persistence after stopping
An article in MHRA's monthly Drug Safety Update bulletin.
Field Safety Notice: 19 to 23 August 2019
A weekly index of the field safety notices manufacturers issued that week.
Microneedling pens: Dermapen 3 and Dermapen Cryo Sterile single use needle cartridge tips for: Dermapen 3 – risk of injury or infection (MDA/2019/028)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Letters and drug alerts sent to healthcare professionals in July 2019
A periodic index page listing other alerts and letters, not a single alert.
Naltrexone/bupropion (Mysimba▼): risk of adverse reactions that could affect ability to drive
An article in MHRA's monthly Drug Safety Update bulletin.
Carfilzomib (Kyprolis▼): reminder of risk of potentially fatal cardiac events
An article in MHRA's monthly Drug Safety Update bulletin.
Daratumumab (Darzalex▼): risk of reactivation of hepatitis B virus
An article in MHRA's monthly Drug Safety Update bulletin.
Medical Devices Alerts issued in July 2019
An article in MHRA's monthly Drug Safety Update bulletin.
Field Safety Notice: 5 to 9 August 2019
A weekly index of the field safety notices manufacturers issued that week.
Field Safety Notice: 29 July to 2 August 2019
A weekly index of the field safety notices manufacturers issued that week.
Class 2 Medicines Recall: Aripiprazole 1mg/ml oral solution (EL (19)A/20)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Field Safety Notice: 22 to 26 July 2019
A weekly index of the field safety notices manufacturers issued that week.
FMD Alert: Class 2 (EL (19)A/19)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Automated external defibrillators: All Telefunken HR1 & FA1 – no valid CE certificate (MDA/2019/027)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Field Safety Notice: 15 to 19 July 2019
A weekly index of the field safety notices manufacturers issued that week.
Professional use capillary blood specimen collection: BD Microtainer® tubes – risk of blood leakage and/or incorrect test results due to defective tubes
Class 2 Medicines Recall: Bisacodyl 5mg Gastro-Resistant tablets batch 25074A (MDR 34-04/19)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Tocilizumab (RoActemra): rare risk of serious liver injury including cases requiring transplantation
An article in MHRA's monthly Drug Safety Update bulletin.
Febuxostat (Adenuric): increased risk of cardiovascular death and all-cause mortality in clinical trial in patients with a history of major cardiovascular disease
An article in MHRA's monthly Drug Safety Update bulletin.
Letters and drug alerts sent to healthcare professionals in June 2019
A periodic index page listing other alerts and letters, not a single alert.
Medical Device Alerts issued in June 2019
A periodic index page listing other alerts and letters, not a single alert.
Rivaroxaban (Xarelto▼): reminder that 15 mg and 20 mg tablets should be taken with food
An article in MHRA's monthly Drug Safety Update bulletin.
Field Safety Notice: 8 to 12 July 2019
A weekly index of the field safety notices manufacturers issued that week.
Class 4 Medicines Defect Information: Emerade 150, 300 and 500 microgram solution for injection in pre-filled syringe (MDR 55-06/18)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
About this source
Individual alerts by type
Read the chart values
| Alert type | Individual alerts |
|---|---|
| Drug Safety Update | 713 |
| Class 1 Medicines Recall | 6 |
| Class 2 Medicines Recall | 159 |
| Class 3 Medicines Recall | 68 |
| Class 4 Medicines Defect Information | 179 |
| Company-Led Medicines Recall | 35 |
| Device Safety Information | 21 |
| Medical Device Alert | 40 |
| National Patient Safety Alert | 11 |
| MHRA Safety Roundup | 16 |
| Unclassified | 253 |
The MHRA regulates medicines and medical devices in the UK and publishes safety communications on GOV.UK in two streams: the monthly Drug Safety Update bulletin, and Alerts and recalls for drugs and medical devices. This page holds 2,267 of those publications, issued between October 2009 and July 2026.
MHRA classes a medicines recall by the hazard the defect presents: Class 1 life-threatening or serious, Class 2 could cause illness or mistreatment, Class 3 unlikely to cause harm, and Class 4 a caution in use rather than a recall, with the product staying available. A device notice is published as Device Safety Information, or, until 2021, as a Medical Device Alert.
What is not here. We hold each publication's title, type, date and link, not its text: read the alert on GOV.UK for the affected products and the actions MHRA asks for. An alert names a medicine or device and a clinical audience, not an organisation, so no alert on this page is linked to an NHS trust or other responsible body. The weekly “Field Safety Notices” pages are MHRA's own index of the notices manufacturers issued that week, not single alerts, and are counted separately above.