Field Safety Notices - 6 to 9 April 2020
A weekly index of the field safety notices manufacturers issued that week.
Source · Drug & device safety alerts
MHRA Drug & Device Safety Alerts
1,501 individual alerts
447 medicines recalls & defect notices
766 weekly / monthly index pages
Oct 2009 – Jul 2026
Drug safety updates, medicines recalls, device safety information and field safety notices published by the Medicines and Healthcare products Regulatory Agency. Source: MHRA alerts and recalls on GOV.UK.
Showing 2,267 publications of 2,267
COVID-19: All haemofiltration systems including machines and accessories – serious risks if users don’t follow manufacturer instructions for set-up (MDA/2020/013)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Anaesthetic machines: off-label use during the COVID-19 pandemic (MDA/2020/012)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Class 2 Medicines Recall: Emerade 300 micrograms solution for injection in pre-filled syringe, PL 33616/0014 (EL(20)A/20)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Field Safety Notices - 30 March to 3 April 2020
A weekly index of the field safety notices manufacturers issued that week.
Spinal implant: All MAGEC Systems – supply suspended to the UK (MDA/2020/011)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Class 4 Medicines Defect Information: Rosemont Pharmaceuticals Ltd, Paracetamol 250mg/5ml Oral Suspension (500ml) PL 00427/0078 EL (20)A/19
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Field Safety Notices - 23 to 27 March 2020
A weekly index of the field safety notices manufacturers issued that week.
Class 4 Medicines Defect Information: Zamadol SR 50 mg prolonged-release hard capsules, PL 46302/0149 (EL (20)A/18)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Field Safety Notices - 16 to 20 March 2020
A weekly index of the field safety notices manufacturers issued that week.
Class 4 FMD Medicines Information: WDA(H) 50340 HMS Wholesale Limited, Multiple Products, (EL (20)A/17)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Letters and drug alerts sent to healthcare professionals in February 2020
A periodic index page listing other alerts and letters, not a single alert.
Benzodiazepines and opioids: reminder of risk of potentially fatal respiratory depression
An article in MHRA's monthly Drug Safety Update bulletin.
SGLT2 inhibitors: monitor ketones in blood during treatment interruption for surgical procedures or acute serious medical illness
An article in MHRA's monthly Drug Safety Update bulletin.
Baricitinib (Olumiant▼): risk of venous thromboembolism
An article in MHRA's monthly Drug Safety Update bulletin.
Tofacitinib (Xeljanz▼): new measures to minimise risk of venous thromboembolism and of serious and fatal infections
An article in MHRA's monthly Drug Safety Update bulletin.
Esmya (ulipristal acetate): suspension of the licence due to risk of serious liver injury
An article in MHRA's monthly Drug Safety Update bulletin.
Update: Class 2 Medicines Recall: Esmya 5mg tablets, EU/1/12/750/001-5, (EL(20)A/16)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Spinal implant: MAGEC System Model X rods – risk of failure in use (MDA/2020/010)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Medical Device Alerts issued in February 2020
A periodic index page listing other alerts and letters, not a single alert.
Field Safety Notices - 9 to 13 March 2020
A weekly index of the field safety notices manufacturers issued that week.
Class 4 Medicines Defect Information: Aripiprazole 1mg/ml Oral Solution, PL 04569/1667, (EL(20)A/15)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Field Safety Notices - 2 to 6 March 2020
A weekly index of the field safety notices manufacturers issued that week.
Class 2 Medicines Recall: Emerade 150 micrograms solution for injection in pre-filled syringe, PL 33616/0013 (EL(20)A/14)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Field Safety Notices - 24 to 28 February 2020
A weekly index of the field safety notices manufacturers issued that week.
Class 2 Medicines Recall: AOP Orphan Pharmaceuticals AG, Tetrabenazine 25 mg tablets, PL 21344/0015, (EL (20)A/13)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Class 4 Medicines Defect Information: Oxylan Prolonged-release tablets, all strengths (oxycodone hydrochloride), (EL (20)/A12)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Tympanic thermometers – revision of the calibration frequency of Cardinal Health Genius 2 and Genius 3 models
Various Olympus duodenoscope models: do not use if elevator wires are frayed or damaged as these may cause lacerations to patients and users (MDA/2020/008)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Class 4 Medicines Defect Information: Memantine 10mg Film-Coated Tablets, PL 20416/0260, (EL (20)A/11)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
All T34 and T34L (T60) ambulatory syringe pumps – check pumps before each use due to risk of under-infusion and no alarm (MDA/2020/007)
Medical Device Alert (MDA): the format MHRA used for device alerts until 2021.
Field Safety Notices - 17 to 21 February 2020
A weekly index of the field safety notices manufacturers issued that week.
Class 4 Drug Alert: Crescent Pharma Ltd and Flamingo Pharma (UK) Ltd, Ibuprofen 400mg Tablets, (EL (20)A/10)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Class 4 FMD Medicines Defect Information: Diamorphine Hydrochloride BP 100 mg Lyophilisate for Solution for Injection, PL 20075/0675, (EL (20)A/09)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Field Safety Notices - 10 to 14 February 2020
A weekly index of the field safety notices manufacturers issued that week.
Class 2 Medicines recall: Accord-UK Ltd, Gliclazide 40 mg Tablets (Northstar Livery), PL 20075/0687, (EL (20)A/08)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Class 4 Medicines Defect Information: Atrolak XL Prolonged-release tablets, all strengths (quetiapine fumarate)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Class 3 FMD Medicines Recall, Beconase Aqueous Nasal Spray, (Beclometasone Dipropionate 50μg), PL 10949/0104, EL (20)A/07
MHRA class: the defect is unlikely to cause harm; recall is on other grounds.
Medical Device Alerts issued in January 2020
A periodic index page listing other alerts and letters, not a single alert.
Support Yellow Card: report suspected reactions in patients taking multiple medicines
An article in MHRA's monthly Drug Safety Update bulletin.
Ingenol mebutate gel (Picato▼): suspension of the licence due to risk of skin malignancy
An article in MHRA's monthly Drug Safety Update bulletin.
Nexplanon (etonogestrel) contraceptive implants: new insertion site to reduce rare risk of neurovascular injury and implant migration
An article in MHRA's monthly Drug Safety Update bulletin.
Lemtrada▼ (alemtuzumab): updated restrictions and strengthened monitoring requirements following review of serious cardiovascular and immune-mediated reactions
An article in MHRA's monthly Drug Safety Update bulletin.
Letters and drug alerts sent to healthcare professionals in January 2020
A periodic index page listing other alerts and letters, not a single alert.
Valproate (Epilim▼, Depakote▼) pregnancy prevention programme: updated educational materials
An article in MHRA's monthly Drug Safety Update bulletin.
Field Safety Notices - 3 to 7 February 2020
A weekly index of the field safety notices manufacturers issued that week.
Company led drug alert – Iohexol solution for injection (350mg/ml and 300 mgI/ml)
A recall the marketing authorisation holder initiated, published by MHRA.
Field Safety Notice: 27 to 31 January
A weekly index of the field safety notices manufacturers issued that week.
Class 2 Medicines recall: Medreich PLC, Ranitidine 150mg Tablets, PL 21880/0091, Ranitidine 300mg Tablets, PL 21880/0092 (EL (20)A/05)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Class 2 Medicines Recall: Wockhardt UK Ltd, Levothyroxine 100micrograms/5ml Oral Solution EL(20)A/04
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
About this source
Individual alerts by type
Read the chart values
| Alert type | Individual alerts |
|---|---|
| Drug Safety Update | 713 |
| Class 1 Medicines Recall | 6 |
| Class 2 Medicines Recall | 159 |
| Class 3 Medicines Recall | 68 |
| Class 4 Medicines Defect Information | 179 |
| Company-Led Medicines Recall | 35 |
| Device Safety Information | 21 |
| Medical Device Alert | 40 |
| National Patient Safety Alert | 11 |
| MHRA Safety Roundup | 16 |
| Unclassified | 253 |
The MHRA regulates medicines and medical devices in the UK and publishes safety communications on GOV.UK in two streams: the monthly Drug Safety Update bulletin, and Alerts and recalls for drugs and medical devices. This page holds 2,267 of those publications, issued between October 2009 and July 2026.
MHRA classes a medicines recall by the hazard the defect presents: Class 1 life-threatening or serious, Class 2 could cause illness or mistreatment, Class 3 unlikely to cause harm, and Class 4 a caution in use rather than a recall, with the product staying available. A device notice is published as Device Safety Information, or, until 2021, as a Medical Device Alert.
What is not here. We hold each publication's title, type, date and link, not its text: read the alert on GOV.UK for the affected products and the actions MHRA asks for. An alert names a medicine or device and a clinical audience, not an organisation, so no alert on this page is linked to an NHS trust or other responsible body. The weekly “Field Safety Notices” pages are MHRA's own index of the notices manufacturers issued that week, not single alerts, and are counted separately above.