Source · Prevention of Future Deaths

Kathryn Bull

Ref: 2016-0188 Date: 27 Apr 2016 Coroner: Henrietta Hill Area: London Greater Inner South Responses identified: 0 / 1 View PDF

Death was caused by hyperammonaemia syndrome, a rare and poorly understood adverse consequence of gastric bypass surgery, with symptoms that are not well known.

Date 27 Apr 2016
56-day deadline 11 Jul 2016
Responses identified 0 of 1
Other related deaths

Coroner's concerns

AI summary
Death was caused by hyperammonaemia syndrome, a rare and poorly understood adverse consequence of gastric bypass surgery, with symptoms that are not well known.
View full coroner's concerns
(1) accepted the evidence from and to the effect that the medical cause of Mrs Bulls death was multi-organ failure caused by hyperammonaemia syndrome, which on the balance of probabilities had been caused her morbid obsesity and gastric bypass surgery: (2) The pathologists _ Kthe gastric bypass consultant who performed the surgery on Mrs Bull) and I(the consultant intensivist who treated her in hospital) confirmed that hyperammonaemia syndrome has been identified as an adverse consequence of gastric bypass surgery.

(3) However this is extremely rare: there appear to have been only 25 or so reported cases worldwide Very little appears to be known about the condition and so the symptoms are not well understood_

Report sections

Investigation and inquest
KATHRYN BULL, then aged 61 years, died on 4 December 2014. An investigation into her death, and then an inquest was opened The inquest into Mrs Bulls death was resumed, and concluded, by myself on 27 April 2016. The medical cause of Bull's death was:
1.a Multi-organ failure;
1.b Hyperammonaemia syndrome;
1.c Morbid obesity and gastric bypass surgery: The conclusion as to the cause of death was a narrative one to the effect that Mrs Bull died as a result of an extremely rare complication of gastric bypass surgery_
Circumstances of the death
The circumstances of the death are as follows: Bull was morbidly obese_ On medical advice she had had a gastric bypass operation on 19 January 2014.
2) Her immediate post-operative recovery was good and she began a liquid diet: (3) However she gradually found it hard to tolerate the solid food diet that she was advised to follow and often only felt able to eat 2 meals a not 3 (4) She complained of dizziness, lethargy, vomiting 'blacking out'_ These are all unremarkable symptoms of gastric bypass surgery and so did not trigger any concerns in the team monitoring her follow up from the surgery. (5) By October 2014 she was rarely leaving the house. (6) On 19 November 2014 she fell at home and was admitted to Lewisham and Greenwich Hospital The hospital staff were unsure f the cause of her illness but suspected some form of endocrine collapse or failure secondary to prolonged malnutrition and deficiency in trace elements. (8) Her conscious state fluctuated. (9) By 26 November 2014 her ammonia level had risen to 226 pmollL (where a level of 112 pmolIL could lead to a deranged cerebral state) (10)She became less conscious and required intubation, T)She deteroriated further and suffered a cardiac arrest on 4 December 2014, from which she could not be resuscitated, She was pronounced dead at 3.30 pm that Mrs (1) Mrs day and day:
Action should be taken
In my opinion action should be taken to prevent future deaths and believe your organisation has the power to take such action.
Copies sent to
Y Gastric Bypass in Obesity; Volume 23,No. 4, April 2015 may

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Report details

Reference
2016-0188
Date of report
27 April 2016
Coroner
Henrietta Hill
Coroner area
London Greater Inner South

Responses identified

Responses identified 0 of 1
1 response not yet linked

Organisations named in PFD reports are normally expected to respond within 56 days. Deadline: 11 Jul 2016.

Sent to

British Obesity and Metabolic Surgery Society

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