Source · Prevention of Future Deaths

Jonathan Szczepanski

Ref: 2024-0271 Date: 17 May 2024 Coroner: Jayne Wilkes Area: Lincolnshire Responses identified: 1 / 1 View PDF

Inadequate local guidance, software warnings, and discharge documentation regarding NSAID prescribing risks, including PPI use, failed to alert prescribers to critical considerations.

Date 17 May 2024
56-day deadline 12 Jul 2024 est.
Responses identified 1 of 1
Hospital Death (Clinical Procedures and medical management) related deaths

Coroner's concerns

AI summary
Inadequate local guidance, software warnings, and discharge documentation regarding NSAID prescribing risks, including PPI use, failed to alert prescribers to critical considerations.
View full coroner's concerns
There is a lack of local practitioner guidance on the practical implementation of the NICE NSAIDs – prescribing issues documentation. The software being used to prescribe NSAIDs did not automatically generate a specific warning flag to alert the prescriber to the considerations and risk factors in the prescription of NSAIDs (including the use of PPI). Where repeat prescriptions were issued on discharge of a patient from hospital back to community primary care, there was no warning on the discharge documentation to alert the prescriber to the considerations and risk factors in the prescription of NSAIDs (including the use of PPI).

Responses

1 respondent
Lincolnshire Integrated Care Board Integrated Care Board
PDF
Action Planned

The ICB will add a statement to the Lincolnshire Formulary reminding users to prescribe PPIs with NSAIDs, and will highlight NICE guidelines in the Medicines Optimisation newsletter and primary care Bulletin. It will also share a case study at the Medicine Safety Network meeting and the Prescribing Forum. (AI summary)

View full response
Dear Ms Wilkes

In the matter of inquest touching the death of the late Jonathan Paul Szczepanski – Response from Lincolnshire Integrated Care Board

I am responding on behalf of Lincolnshire ICB at the request of our Chief Executive, Mr John Turner, who I have briefed on the case and our response. I have now reviewed your request with contribution from our Medicines Optimisation team and respond to each of the points raised in the report as stated below.

1. There is a lack of local practitioner guidance on the practical implementation of the NICE NSAIDs – prescribing issues documentation.

ICB response It is long-standing accepted practice, as per NICE guidelines, that PPIs should be considered as a co-prescription with NSAIDs for at risk patients.

ICB Actions

1. The ICB will add a statement to the Lincolnshire Formulary in way of a reminder of the use of PPIs with NSAIDs.
2. The ICB will highlight the NICE guidelines in the “hot topic” article in the next Medicines Optimisation newsletter. This will also be shared in the primary care Bulletin.
3. This will be shared as a case study at the Medicine Safety Network meeting and the Prescribing Forum, including a reminder of the NICE guidelines

2. The software being used to prescribe NSAIDs did not automatically generate a specific warning flag to alert the prescriber to the considerations and risk factors in the prescription of NSAIDs (including the use of PPI).

ICB response Lincolnshire ICB has two software systems in place to assist prescribing of NSAIDs, OptimiseRx and Eclipse.

OptimiseRx has an automated alert at the time of prescribing NSAIDs. This comes up as a pop up to remind the clinician issuing the NSAID that they should consider adding a PPI to the prescription. Eclipse generates a weekly report regarding prescriptions of NSAIDs and identifies where co-prescribing of PPIs has not occurred. The practice can use this data to retrospectively review the patient record and add or change the appropriate medication. The ICB is working with all practices to highlight the importance of using these tools.

3. Where repeat prescriptions were issued on discharge of a patient from hospital back to community primary care, there was no warning on the discharge documentation to alert the prescriber to the considerations and risk factors in the prescription of NSAIDs (including the use of PPI).

ICB response At the point of discharge from hospital a list of all medications is produced and is sent to the relevant GP practice. The ICB understands that the Trust is putting in place an electronic patient record that should make this more visible. We will work with the Trust to develop systems that promote safer prescribing which will include work with the safety lead to resend a reminder of the importance of co-prescribing a PPI with NSAID, and we plan to monitor this through our Quality forum.

We are committed to working collaboratively with our relevant partners to implement changes from the lessons learnt from this case. Should you require and further information or clarification on any of the points please do not hesitate to contact me.

Your faithfully

Medical Director Lincolnshire ICB

Report sections

Investigation and inquest
On 31 May 2023 I commenced an investigation into the death of Jonathan Paul SZCZEPANSKI aged 64.   The investigation concluded at the end of the inquest on Monday 13 May 2024. The conclusion of the inquest was:  

Medical cause of death: 1(a) Upper Gastrointestinal Haemorrhage 1(b) Duodenal Ulcer 2    Naproxen Treatment  

Conclusion Mr Jonathan Paul Szczepanski died from the consequence of a duodenal ulcer to which the prescription of Naproxen without the corresponding Protein Pump Inhibitor (PPI) made a contribution.
Circumstances of the death
Mr Jonathan Paul Szczepanski had a significant medical history which included Parkinson’s Disease, Type 2 Diabetes, Hypertension and Spinal Stenosis. He had several repeat prescriptions from his GP surgery to treat his conditions and to provide pain relief. This included Naproxen, a non-steroid anti-inflammatory drug (NSAID) which had been prescribed regularly since 2016 on a dosage level of 500mg twice daily. No corresponding proton pump inhibitor (PPI) medication had ever been prescribed to address the recognised risk of duodenal ulceration from NSAIDs. No medication reviews had taken place to address or manage the risks of long term NSAID prescription, against the background of his relevant co-morbidities. He was admitted to Boston Pilgrim Hospital on 28 April 2023 with an acute kidney injury due to suspected infection and urinary retention. He was discharged on 2 May 2023 with a repeat prescription of Naproxen – 500mg twice daily. No PPI medication was prescribed. He was admitted to Boston Hospital on 14 May 2023 with symptoms indicative of a gastrointestinal bleed. Despite repeated medical and surgical intervention, he did not respond to treatment and his condition was such that further intervention was not possible. He was placed on end-of-life care until he passed away.
Copies sent to
[REDACTED], Welby Group, The New Coningsby Surgery, 20 Silver Street, Coningsby, Lincolnshire, LN4 4SG United Lincolnshire Hospitals NHS Trust

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Report details

Reference
2024-0271
Date of report
17 May 2024
Coroner
Jayne Wilkes
Coroner area
Lincolnshire

Responses identified

Responses identified 1 of 1
All listed responses identified

Organisations named in PFD reports are normally expected to respond within 56 days. Deadline: 12 Jul 2024 (estimated).

Sent to

Lincolnshire Integrated Care Board

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