Source · Drug & device safety alerts
MHRA Drug & Device Safety Alerts
1,501 individual alerts
447 medicines recalls & defect notices
766 weekly / monthly index pages
Oct 2009 – Jul 2026
Drug safety updates, medicines recalls, device safety information and field safety notices published by the Medicines and Healthcare products Regulatory Agency. Source: MHRA alerts and recalls on GOV.UK.
Showing 2,267 publications of 2,267
Field safety notices - 26 to 30 October 2015
A weekly index of the field safety notices manufacturers issued that week.
All batches of Marcain Polyamp Steripack 0.5% (bupivacaine hydrochloride) - error on carton and ampoule label about administration
Field safety notices - 19 to 23 October 2015
A weekly index of the field safety notices manufacturers issued that week.
Bravelle 75IU powder for solution for injection - Ferring Pharmaceuticals Limited (CLDA (15)A/08) - 22 October 2015
Field safety notices - 12 to 16 October 2015
A weekly index of the field safety notices manufacturers issued that week.
Testicular implants and inflatable vaginal stents – temporary suspension of the CE certificate
Mirabegron (Betmiga▼): risk of severe hypertension and associated cerebrovascular and cardiac events
An article in MHRA's monthly Drug Safety Update bulletin.
Letters sent to healthcare professionals in September 2015
A periodic index page listing other alerts and letters, not a single alert.
Field safety notices - 5 to 9 October 2015
A weekly index of the field safety notices manufacturers issued that week.
Field safety notices - 28 September to 2 October 2015
A weekly index of the field safety notices manufacturers issued that week.
Medical device alerts archived in September 2015
A periodic index page listing other alerts and letters, not a single alert.
Implantable medical devices manufactured by Silimed lndustria de lmplantes Ltda - temporary suspension of the CE certificate
Field safety notices - 21 to 25 September 2015
A weekly index of the field safety notices manufacturers issued that week.
Lacri-Lube Eye Ointment - small black particles on or around the nozzle of the tube
Field safety notices - 14 to 18 September 2015
A weekly index of the field safety notices manufacturers issued that week.
Topotecan Medac 1mg/ml concentrate for solution for infusion, 1x4ml - Medac GmbH - CLDA (15)A/07 - 18 September 2015
Field safety notices - 7 to 11 September 2015
A weekly index of the field safety notices manufacturers issued that week.
Pseudoephedrine and ephedrine: update on managing risk of misuse in the UK
An article in MHRA's monthly Drug Safety Update bulletin.
Proton pump inhibitors: very low risk of subacute cutaneous lupus erythematosus
An article in MHRA's monthly Drug Safety Update bulletin.
Download the Yellow Card mobile app to report suspected adverse drug reactions
An article in MHRA's monthly Drug Safety Update bulletin.
Letters sent to healthcare professionals in August 2015
A periodic index page listing other alerts and letters, not a single alert.
Field safety notices - 31 August to 4 September 2015
A weekly index of the field safety notices manufacturers issued that week.
Field safety notices - 24 to 28 August 2015
A weekly index of the field safety notices manufacturers issued that week.
Bactroban 2% nasal ointment 3g/ Bactroban 2% cream 15g - Beecham Group plc trading as GlaxoSmithKline UK (CLDA (15)A/06) - 24 August 2015
Field safety notices - 17 to 21 August 2015
A weekly index of the field safety notices manufacturers issued that week.
Simeprevir with sofosbuvir: risk of severe bradycardia and heart block when taken with amiodarone
An article in MHRA's monthly Drug Safety Update bulletin.
Letters sent to healthcare professionals in July 2015
A periodic index page listing other alerts and letters, not a single alert.
Field safety notices - 10 to 14 August 2015
A weekly index of the field safety notices manufacturers issued that week.
Pregabalin 75mg capsules - incorrect strength printed in one area of foil blister pack
Medical device alerts archived in July 2015
A periodic index page listing other alerts and letters, not a single alert.
Field safety notices - 3 to 7 August 2015
A weekly index of the field safety notices manufacturers issued that week.
Field safety notices - 27 to 31 July 2015
A weekly index of the field safety notices manufacturers issued that week.
Chirocaine 5mg/ml solution for injection/concentrate - Abbvie Limited - CLDA (15)A/05 - 30 July 2015
Field safety notices - 20 to 24 July 2015
A weekly index of the field safety notices manufacturers issued that week.
Latanoprost (Xalatan): increased reporting of eye irritation since reformulation
An article in MHRA's monthly Drug Safety Update bulletin.
Letters sent to healthcare professionals in June 2015
A periodic index page listing other alerts and letters, not a single alert.
New Yellow Card app for reporting suspected side effects
An article in MHRA's monthly Drug Safety Update bulletin.
Denosumab (Xgeva▼, Prolia); intravenous bisphosphonates: osteonecrosis of the jaw—further measures to minimise risk
An article in MHRA's monthly Drug Safety Update bulletin.
Field safety notices - 13 to 17 July 2015
A weekly index of the field safety notices manufacturers issued that week.
Propofol 10mg/ml (1%) Emulsion for Injection/Infusion 50ml presentation - incorrect colour identifying volume on package
Field safety notices - 6 to 13 July 2015
A weekly index of the field safety notices manufacturers issued that week.
TransWarmer infant transport mattress, NovaPlus TransWarmer infant heat therapy mattress with WarmGel, infant heel warmer - risk of serious burn
Field safety notices - 29 June to 3 July 2015
A weekly index of the field safety notices manufacturers issued that week.
Xenidate XL 36mg prolonged-release tablets (methylphenidate hydrochloride) - incorrect number of tablets in packs from a specific batch
SGLT2 inhibitors (canagliflozin, dapagliflozin, empagliflozin): risk of diabetic ketoacidosis
An article in MHRA's monthly Drug Safety Update bulletin.
Hormonal pregnancy tests and birth defects: call for evidence
An article in MHRA's monthly Drug Safety Update bulletin.
Intrauterine contraception: uterine perforation—updated information on risk factors
An article in MHRA's monthly Drug Safety Update bulletin.
Survey of medicines safety communications
An article in MHRA's monthly Drug Safety Update bulletin.
High-dose ibuprofen (≥2400mg/day): small increase in cardiovascular risk
An article in MHRA's monthly Drug Safety Update bulletin.
About this source
Individual alerts by type
Read the chart values
| Alert type | Individual alerts |
|---|---|
| Drug Safety Update | 713 |
| Class 1 Medicines Recall | 6 |
| Class 2 Medicines Recall | 159 |
| Class 3 Medicines Recall | 68 |
| Class 4 Medicines Defect Information | 179 |
| Company-Led Medicines Recall | 35 |
| Device Safety Information | 21 |
| Medical Device Alert | 40 |
| National Patient Safety Alert | 11 |
| MHRA Safety Roundup | 16 |
| Unclassified | 253 |
The MHRA regulates medicines and medical devices in the UK and publishes safety communications on GOV.UK in two streams: the monthly Drug Safety Update bulletin, and Alerts and recalls for drugs and medical devices. This page holds 2,267 of those publications, issued between October 2009 and July 2026.
MHRA classes a medicines recall by the hazard the defect presents: Class 1 life-threatening or serious, Class 2 could cause illness or mistreatment, Class 3 unlikely to cause harm, and Class 4 a caution in use rather than a recall, with the product staying available. A device notice is published as Device Safety Information, or, until 2021, as a Medical Device Alert.
What is not here. We hold each publication's title, type, date and link, not its text: read the alert on GOV.UK for the affected products and the actions MHRA asks for. An alert names a medicine or device and a clinical audience, not an organisation, so no alert on this page is linked to an NHS trust or other responsible body. The weekly “Field Safety Notices” pages are MHRA's own index of the notices manufacturers issued that week, not single alerts, and are counted separately above.