Source · Drug & device safety alerts
MHRA Drug & Device Safety Alerts
1,501 individual alerts
447 medicines recalls & defect notices
766 weekly / monthly index pages
Oct 2009 – Jul 2026
Drug safety updates, medicines recalls, device safety information and field safety notices published by the Medicines and Healthcare products Regulatory Agency. Source: MHRA alerts and recalls on GOV.UK.
Showing 2,267 publications of 2,267
Spironolactone and renin-angiotensin system drugs in heart failure: risk of potentially fatal hyperkalaemia—clarification, December 2016
An article in MHRA's monthly Drug Safety Update bulletin.
Field Safety Notices - 28 November - 2 December 2016
A weekly index of the field safety notices manufacturers issued that week.
Evacal D3 1500mg/400iu Chewable Tablets - metal contamination in a very small number of tablets
Field Safety Notices - 21 - 25 November 2016
A weekly index of the field safety notices manufacturers issued that week.
Field safety notices - 14 November - 18 November 2016
A weekly index of the field safety notices manufacturers issued that week.
Field safety notices - 7 November - 11 November 2016
A weekly index of the field safety notices manufacturers issued that week.
Show your support for reporting suspected adverse drug reactions
An article in MHRA's monthly Drug Safety Update bulletin.
Brimonidine gel (Mirvaso): risk of exacerbation of rosacea
An article in MHRA's monthly Drug Safety Update bulletin.
Letters sent to healthcare professionals in October 2016
A periodic index page listing other alerts and letters, not a single alert.
Hydrocortisone 100mg/1ml Solution for Injection - solution in some ampoules has a yellowish appearance
Field Safety Notices - 31 October - 4 November 2016
A weekly index of the field safety notices manufacturers issued that week.
Field Safety Notices - 24 - 28 October 2016
A weekly index of the field safety notices manufacturers issued that week.
Total intravenous anaesthesia sets (TIVA) – risk of leakage during use
Medical device alerts archived in October 2016
A periodic index page listing other alerts and letters, not a single alert.
Managing diabetes: patients should not change their insulin delivery device without checking with their healthcare specialist
Field safety notices - 17 - 21 October 2016
A weekly index of the field safety notices manufacturers issued that week.
Class 2 medicines recall: Nacrez 75 microgram Film-coated Tablets (Desogestrel) PL 00289/1706
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Field Safety Notices - 10 - 14 October 2016
A weekly index of the field safety notices manufacturers issued that week.
Letters sent to healthcare professionals in September 2016, including retigabine withdrawal
A periodic index page listing other alerts and letters, not a single alert.
Etoricoxib (Arcoxia): revised dose recommendation for rheumatoid arthritis and ankylosing spondylitis
An article in MHRA's monthly Drug Safety Update bulletin.
Implantable cardioverter defibrillators (ICD) and cardiac resynchronisation therapy devices (CRT-D) – risk of loss of therapy due to rapid battery depletion
Field Safety Notices - 3 - 7 October 2016
A weekly index of the field safety notices manufacturers issued that week.
Field Safety Notices - 26 - 30 September 2016
A weekly index of the field safety notices manufacturers issued that week.
Adalat LA 60mg Tablets incorrectly packaged in 30mg carton (CLDA (16)A/08)
Field Safety Notices - 12 - 16 September 2016
A weekly index of the field safety notices manufacturers issued that week.
Field Safety Notices - 19 - 23 September 2016
A weekly index of the field safety notices manufacturers issued that week.
Chlorhexidine Gluconate 2%w/v impregnated pad - precautionary recall (CLDA (16)A/07)
Class 4 Caution in Use: EcoLab Klerpack BD Syringe Multi-Pack
Letters sent to healthcare professionals in August 2016
A periodic index page listing other alerts and letters, not a single alert.
Posaconazole (Noxafil): tablets and oral suspension are not directly interchangeable
An article in MHRA's monthly Drug Safety Update bulletin.
Idelalisib (Zydelig▼): updated indications and advice on minimising the risk of infection
An article in MHRA's monthly Drug Safety Update bulletin.
Levonorgestrel-containing emergency hormonal contraception: advice on interactions with hepatic enzyme inducers and contraceptive efficacy
An article in MHRA's monthly Drug Safety Update bulletin.
Field Safety Notices - 5 - 9 September 2016
A weekly index of the field safety notices manufacturers issued that week.
Class 2 medicines recall: GlucaGen HypoKit 1mg (glucagon) PL 04668/0027 (GlucaGen 1mg) PL 04668/0028 (Solvent for GlucaGen 1mg)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Field Safety Notices - 29 August - 2 September 2016
A weekly index of the field safety notices manufacturers issued that week.
Accu-Chek® Insight Insulin pump system: risk of over- or under-infusion of insulin
Field Safety Notices - 22 - 26 August 2016
A weekly index of the field safety notices manufacturers issued that week.
Class 4 Caution in Use: Actilyse 20mg and 50mg powder and solvent for solution for injection and infusion (alteplase)
Field Safety Notices - 15 - 19 August 2016
A weekly index of the field safety notices manufacturers issued that week.
Field safety Notice - 8 August to 12 August
A weekly index of the field safety notices manufacturers issued that week.
Kogenate Bayer Powder and Solvent for Solution for Injection - (CLDA (16)A/05)
Helixate NexGen - (CLDA (16)A/06)
Class 2 medicines recall: Respontin Nebules 250micrograms/1ml & Respontin Nebules 500micrograms/2ml (Ipratropium Bromide)
MHRA class: the defect could cause illness or mistreatment, but is not Class 1.
Furosemide-Claris 20mg/2ml Injection - AUST R 148003, intended for the Australian market (CLDA (16)A/04)
Letters sent to healthcare professionals in July 2016
A periodic index page listing other alerts and letters, not a single alert.
Riociguat (Adempas): not for use in patients with pulmonary hypertension associated with idiopathic interstitial pneumonias
An article in MHRA's monthly Drug Safety Update bulletin.
Field Safety Notices - 1 - 5 August 2016
A weekly index of the field safety notices manufacturers issued that week.
NuTRIflex Lipid special 1875ml PL 03551/0031 (Batch number 160338052)
Field Safety Notices - 25 July - 29 July 2016
A weekly index of the field safety notices manufacturers issued that week.
About this source
Individual alerts by type
Read the chart values
| Alert type | Individual alerts |
|---|---|
| Drug Safety Update | 713 |
| Class 1 Medicines Recall | 6 |
| Class 2 Medicines Recall | 159 |
| Class 3 Medicines Recall | 68 |
| Class 4 Medicines Defect Information | 179 |
| Company-Led Medicines Recall | 35 |
| Device Safety Information | 21 |
| Medical Device Alert | 40 |
| National Patient Safety Alert | 11 |
| MHRA Safety Roundup | 16 |
| Unclassified | 253 |
The MHRA regulates medicines and medical devices in the UK and publishes safety communications on GOV.UK in two streams: the monthly Drug Safety Update bulletin, and Alerts and recalls for drugs and medical devices. This page holds 2,267 of those publications, issued between October 2009 and July 2026.
MHRA classes a medicines recall by the hazard the defect presents: Class 1 life-threatening or serious, Class 2 could cause illness or mistreatment, Class 3 unlikely to cause harm, and Class 4 a caution in use rather than a recall, with the product staying available. A device notice is published as Device Safety Information, or, until 2021, as a Medical Device Alert.
What is not here. We hold each publication's title, type, date and link, not its text: read the alert on GOV.UK for the affected products and the actions MHRA asks for. An alert names a medicine or device and a clinical audience, not an organisation, so no alert on this page is linked to an NHS trust or other responsible body. The weekly “Field Safety Notices” pages are MHRA's own index of the notices manufacturers issued that week, not single alerts, and are counted separately above.