Oral diclofenac no longer available without prescription
An article in MHRA's monthly Drug Safety Update bulletin.
Source · Drug & device safety alerts
MHRA Drug & Device Safety Alerts
1,501 individual alerts
447 medicines recalls & defect notices
766 weekly / monthly index pages
Oct 2009 – Jul 2026
Drug safety updates, medicines recalls, device safety information and field safety notices published by the Medicines and Healthcare products Regulatory Agency. Source: MHRA alerts and recalls on GOV.UK.
Showing 2,267 publications of 2,267
Yellow Card extended to include devices, counterfeits and defective medicines
An article in MHRA's monthly Drug Safety Update bulletin.
Ustekinumab (Stelara): risk of exfoliative dermatitis
An article in MHRA's monthly Drug Safety Update bulletin.
Aceclofenac (Preservex): updated cardiovascular advice in line with diclofenac and COX-2 inhibitors
An article in MHRA's monthly Drug Safety Update bulletin.
Mycophenolate mofetil (CellCept) and mycophenolic acid: risk of hypogammaglobulinaemia and risk of bronchiectasis
An article in MHRA's monthly Drug Safety Update bulletin.
Field safety notices - 12 to 16 January 2015
A weekly index of the field safety notices manufacturers issued that week.
Oral diclofenac presentations with legal status ‘P’ – reclassified to POM
Veletri (epoprostenol) powder for solution for infusion: incompatibilities with some models of administration devices
An article in MHRA's monthly Drug Safety Update bulletin.
Hydrogen peroxide: reminder of risk of gas embolism when used in surgery
An article in MHRA's monthly Drug Safety Update bulletin.
Ebixa 5mg/pump actuation 50ml and 100ml bottle - fault with some of the pump devices
Ivabradine (Procoralan) in the symptomatic treatment of angina: risk of cardiac side effects
An article in MHRA's monthly Drug Safety Update bulletin.
Isotretinoin (Roaccutane): reminder of possible risk of psychiatric disorders
An article in MHRA's monthly Drug Safety Update bulletin.
Hydroxyethyl starch intravenous infusions
An article in MHRA's monthly Drug Safety Update bulletin.
Motilium 10 10mg Tablets and Motilium Instants10mg – changed to prescription-only medicine
Idarubicin 1mg/ml injection 5 & 10 ml - recall
Buccolam Oromucosal Solution - possibility for chemical contamination
Amoxicillin Sodium 500mg powder for solution for injection - additional reports of injection site reactions in paediatrics and adults
Midazolam Buccal Liquid 10mg / 1ml, 5ml - screw caps not been correctly placed
Breast implants - report cases of anaplastic large cell lymphoma (ALCL)
Amoxicillin Sodium 250mg, 500g, & 1mg powder for solution for injection - reports of extravasation and injection site reactions
Fybogel Hi-Fibre and Fybogel Orange - potential risk of contamination with metal particles
Clarithromycin 500mg Powder for Solution for Infusion - small particles of white material to be present in individual vials
Vancomycin Powder for Concentrate for Solution for Infusion - small particles of fibre material and glass in individual vials
Lipid Phase only of Parenteral Nutrition - potential contamination with Bacillus cereus
Heated humidifiers used in combination with heated-wire breathing systems - risk of oxygen-fuelled fire
Paradigm ambulatory insulin infusion pumps - risk of hypoglycaemia
Unicondylar sled knee prosthesis - risk of early wear
All Pace Medical Inc temporary pacemakers and pacing system analysers (PSAs) – CE marking suspended
Fybogel Orange - risk of contamination with metal particles
Insulin infusion pump - risk of delay in treatment
Viread 245 mg film-coated tablets - possible presence of silicone rubber
Intra-oral dental X-ray units: Kodak 2100 and Kodak 2200 - risk of injury
COSOPT preservative-free, 20mg/ml +5mg/ml, eye drops, solution, single-dose container - difficulties with administration
Counterfeit or non-CE marked dental medical devices
Irbesartan / Hydrochorothiazide Teva 300/12.5mg and 300/25mg film-coated tablets - incorrect dosing instruction in patient information leaflet
Irbesartan 300mg film-coated tablets - blisters is incorrectly labelled as Irbesartan 150mg
Implantable pacemakers - residual longevity overestimated
Methotrexate 25mg/ml injection - damaged vials
Tixylix® liquid medicines - small pieces of plastic being found in medicine
Class 4 drug alert (caution in use): Matrifen 100 micrograms/hour Transdermal Patch, Teva UK Livery - Takeda UK Limited (EL (13)A/29)
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Jext 300 and 150 micrograms solution for injection in pre-filled pens - problem with delivery of dosage
Class 4 Drug Alert (Caution in Use): 8.4% w/v Sodium Bicarbonate - B. Braun Melsungen AG - PL 03551/0069
MHRA class: a minor defect; the product stays available with a caution in use, not a recall.
Plum A+ and A+3 family of infusers, Gemstar infuser and Lifecare PCA infuser - CE marking withdrawn
Imigran Injection/Subject - syringes may have needles protruding from the needle shield
NovoMix 30 Penfill 100U/ml, 3ml and NovoMix 30 FlexPen 100U/ml, 3ml – cartridges contain too much or too little insulin in batches
Multiple products by Wockhardt UK Limited – 2nd site certificate withdrawn
Natzon 0.4mg Sublingual Tablets - wrong blister packs in cartons
Bydureon 2mg powder and solvent - may contain small number of under-filled vials
Warfarin 3mg tablets - higher than expected levels of degradation
Wheeled and non-wheeled walking frames (all models) - potential for detachment of the wheels and/or inadequately tightened screws
About this source
Individual alerts by type
Read the chart values
| Alert type | Individual alerts |
|---|---|
| Drug Safety Update | 713 |
| Class 1 Medicines Recall | 6 |
| Class 2 Medicines Recall | 159 |
| Class 3 Medicines Recall | 68 |
| Class 4 Medicines Defect Information | 179 |
| Company-Led Medicines Recall | 35 |
| Device Safety Information | 21 |
| Medical Device Alert | 40 |
| National Patient Safety Alert | 11 |
| MHRA Safety Roundup | 16 |
| Unclassified | 253 |
The MHRA regulates medicines and medical devices in the UK and publishes safety communications on GOV.UK in two streams: the monthly Drug Safety Update bulletin, and Alerts and recalls for drugs and medical devices. This page holds 2,267 of those publications, issued between October 2009 and July 2026.
MHRA classes a medicines recall by the hazard the defect presents: Class 1 life-threatening or serious, Class 2 could cause illness or mistreatment, Class 3 unlikely to cause harm, and Class 4 a caution in use rather than a recall, with the product staying available. A device notice is published as Device Safety Information, or, until 2021, as a Medical Device Alert.
What is not here. We hold each publication's title, type, date and link, not its text: read the alert on GOV.UK for the affected products and the actions MHRA asks for. An alert names a medicine or device and a clinical audience, not an organisation, so no alert on this page is linked to an NHS trust or other responsible body. The weekly “Field Safety Notices” pages are MHRA's own index of the notices manufacturers issued that week, not single alerts, and are counted separately above.